OCCUMOX Moxifloxacin 0.5% Eye Ointment

Composition w/v            

Moxifloxacin Hydrochloride        

Equivalent to Moxifloxacin           0.5%

Dosage form

Ophthalmic Solution (Eye Drops)

Category

Antibiotic

Description

Moxifloxacin is an 8-methoxy fluoroquinolone with a diazabicyclononyl ring at the C7 position. The antibacterial action of moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.

Indications

Moxifloxacin ophthalmic solution is indicated for the treatment of bacterial conjunctivitis.

Contraindications

Moxifloxacin ophthalmic solution is contraindicated in patients with a history of hypersensitivity to moxifloxacin, to other quinolones, or to any of the components in this medication.

Warning & Precautions

As with other anti-infectives, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit-lamp biomicroscopy, and, where appropriate, fluorescein staining. Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.

Lactation

Moxifloxacin has not been measured in human milk, although it can be presumed to be excreted in human milk. Caution should be exercised when moxifloxacin solution is administered to a lactating female.

Adverse Effects

The most frequently reported ocular undesirable effects were conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort, ocular hyperemia, ocular pain, ocular pruritus, sub-conjunctival hemorrhage, and tearing. These events occurred in approximately 1-6% of patients.

Storage

Store in a cool dry place. Protect from light.

Presentation

OCCUMOX eye ointment is available in sterile plastic bottle of 5 g.